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Genetic wealth: a millionaire business that does not return to the countries of origin
A United Nations initiative aspires to make large pharmaceutical companies pay for the commercial use of genetic data
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Latest in Bioethics & Dual‑Use
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The race to genetically engineer babies
A biotech entrepreneur has raised $30 million to launch Preventive, a public-benefit company dedicated to studying whether gene-edited babies can be made safely—the largest known investment yet in the field of heritable genome editing, as MIT Technology Review’s Antonio Regalado…
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Gene editing could replace a lifetime of medication, but there's a catch
Imagine receiving a single treatment that could keep your cholesterol under control for decades, potentially eliminating the need for daily medication. Advances in gene editing are bringing that possibility closer to reality. But scientists say the same technology that could…
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Genotoxic safety and long-term engraftment dynamics of efficient translational CRISPR/Cas9 therapeutics for β-haemoglobinopathies from bench to clinical trials
Gene Therapy (2026) Cite this article Following the 2020 PRISMA guidelines, we conducted a systematic review of 21 key clinical and preclinical studies (published during 2014–2026) to evaluate CRISPR/Cas9-mediated gene editing in β-thal and SCD. The inclusion criteria focused on studies reporting foetal…
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As gene editing advances, Harrisites consider its ethical limits
In 2023, the FDA approved CASGEVY, the first treatment in the United States to use CRISPR gene-editing technology. The treatment is used for certain patients with sickle cell disease, a genetic blood disorder that can cause severe pain and other complications.
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CRISPR Breakthrough: First In Vivo Prime Editing Treatment Tested in Humans
For years, scientists have been working on ways to treat genetic disorders that cause serious health problems. Now, a Phase 1/2 clinical trial is testing an experimental prime-editing treatment called PM577a. So far, only one patient has received the treatment, and the…
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Germline Stem Cell Transplantation Proposed to Reduce Mosaicism in Finfish Genome Editing
Researchers are exploring the use of germline stem cell (GSC) culture and transplantation as a method to improve genome editing in finfish aquaculture. This approach aims to address current limitations in the industry by allowing scientists to introduce, validate, and…
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Genomics for CRISPR: An introduction to genomic safety assessment
In recent years, significant milestones have been achieved in CRISPR therapies (Figure 1), including the first in vivo base-editing successes, the approval of CASGEVY, and late-stage clinical progress for in vivo gene editing. Genomic safety has continued to be a critical…
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U.S. scientists create human-pig chimera embryos to grow human cells: ‘This required a tour de force’
Researchers say it may one day be possible to inject human stem cells into pig embryos to grow human organs In what’s being hailed a scientific “tour de force,” American researchers have succeeded in creating human-pig chimera embryos with the…
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A new CRISPR breakthrough allows for the correction of genetic alterations directly within the human body
The genetic blueprint that aims to cure Wilson’s disease directly in the liver The scientific journal Nature recently published a news item by Heidi Ledford entitled “A first for CRISPR: powerful prime editing alters DNA directly in the human body,…
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