Anthropic's research unveils the first 3D structure of vault particles in prokaryotes, advancing understanding of these enigmatic protein assemblies. The vault particles were produced in laboratory E. coli systems, providing researchers with a simpler and faster model for studying their assembly and…
After training the surrogate model, we use an acquisition functions based on parallel upper confidence bound (qUCB)59 to generate new candidates within the current TuR and adjust the hyperparameter β to balance exploration and exploitation. Here, qUCB is defined as:…
A resolution of ~1460 was previously unattainable when imaging using undetectable infrared light around 1550nm. Now, spontaneous parametric down-conversion allows spectrally resolved transmission imaging without directly detecting these wavelengths, demonstrated by successfully mapping attenuation within a zebrafish larva. This silicon-based approach promises…
A new type of compact camera that replaces conventional lenses with engineered optics has been developed by researchers at the University of Washington and Princeton University. The prototype camera uses optics for computing, reducing power consumption and enabling the camera…
All data in this study are available from the corresponding author upon request. Krausz, F. & Ivanov, M. Attosecond physics. Rev. Mod. Phys. 81, 163–234 (2009). Lewenstein, M., Balcou, Ph., Ivanov, M. Yu., L’huillier, A. & Corkum, P. B. Theory of high-harmonic generation by low-frequency laser fields.
Nature volume 659, pages 91–99 (2026) Cite this article Fibre strain measured from the DVC showed a significant positive correlation with fibrillar D-period strain measured from SAXS (r2 = 0.138, P Fibrillar D-period strain showed a significant negative correlation with the initial fibrillar D-period (r2 = 0.312, P Fibre…
Bromine has a characteristic isotopic signature, appearing naturally in two isotopes in a fixed ratio, and this signature transfers to every derivatized metabolite. The authors emphasize that the method is capable of interrogating metabolic heterogeneity in clinically relevant tumor models,…
To test how broadly the approach could reach, the group extended PerCap to mouse tissues and compared the peroxisomal proteomes across different organs. Peroxisomes were also isolated from mouse tissues to compare tissue-specific peroxisomal proteins. PerCap leverages the interaction between…
Scientists from several U.S. Department of Energy National Laboratories gathered at NSLS-II to explore how innovative imaging techniques are helping address common challenges in microelectronics. Recent demonstrations at the National Synchrotron Light Source II (NSLS-II), a DOE Office of Science user…
Nature Methods (2026) Cite this article Beck, M. & Baumeister, W. Cryo-electron tomography: can it reveal the molecular sociology of cells in atomic detail?. Trends Cell Biol. 26, 825–837 (2016). Mahamid, J. et al. Visualizing the molecular sociology at the HeLa cell nuclear periphery. Science 351, 969–972 (2016). McCafferty, C.
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