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Vaccines & Immunology
mRNA platforms, boosters, monoclonals, and immune‑system science.
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Latest in Vaccines & Immunology
Receptor Occupancy Fails to Predict Immune Activation in Pembrolizumab
2+ hour, 45+ min ago (55+ words) Pembrolizumab, one of the most widely prescribed cancer immunotherapies in the world, has long been dosed on the assumption that saturating the PD-1 receptor on T cells is the key to unlocking the immune system against tumours. A new translational…...
Engineered T Cell Receptors With Built-In ICOS Deliver Long-Lasting
2+ hour, 51+ min ago (120+ words) Adoptive T cell therapy has delivered striking remissions in some blood cancers, but its promise in solid tumors has been repeatedly undermined by a stubborn problem: the therapeutic cells do not last. Engineered T cells that flood a tumor and…...
Chromosomal Chaos in Tumors May Blind the Immune System, Genome Study Finds
4+ hour, 20+ min ago (758+ words) Scientists in Japan have taken one of the most detailed looks yet at how large-scale genome disruption inside tumor cells may quietly rewire the immune landscape around them, and their findings could help explain why some cancers mount virtually no…...
New computational tool reads hidden RNA cleavage signals in health and
7+ hour, 8+ min ago (747+ words) For years, biologists catalogued small non-coding RNAs by counting how many of each type appeared in a sequencing run. That approach treated tiny RNA molecules as a census problem, and it worked well enough for microRNAs, the classical regulators of…...
Smart nanoparticles reprogram tumor immune cells to boost cancer attack
21+ hour, 30+ min ago (48+ words) Targeted lipid nanoparticles deliver mRNA to tumor-associated macrophages, reprogramming the immune environment and strengthening anti-cancer T-cell activity in mice. Smart nanoparticles reprogram tumor immune cells to boost cancer attack Targeted lipid nanoparticles deliver mRNA to tumor-associated macrophages, reprogramming the immune…...
Scientists Discover CD55 Is the Hidden Switch That Powers Natural Killer
9+ hour, 16+ min ago (680+ words) Natural killer cells have long been celebrated as the swift, unsung assassins of the immune system, capable of detecting and destroying tumor cells without the elaborate priming that T cells require....
RNA Profiling Splits Deadly Dog Spleen Cancer into Three Actionable
12+ hour, 47+ min ago (88+ words) One of the most lethal cancers in dogs has long frustrated veterinary oncologists with its stubborn one-size-fits-all treatment approach. Now, a research team at the University of São Paulo has shown that canine splenic hemangiosarcoma—a rapidly progressive cancer of…...
Cryo-EM Reveals the Dynamic Machinery That Switches Genes On
13+ hour, 39+ min ago (83+ words) Every cell in the human body carries the same genome, yet a neuron, a hepatocyte, and an immune cell behave in utterly different ways. The difference lies in which genes are switched on, when, and where. That act of switching,…...
Why Blocking One Immune Enzyme Fails: Cells Reroute Tryptophan Metabolism
16+ hour, 6+ min ago (743+ words) For more than a decade, the enzyme indoleamine 2,3-dioxygenase 1, better known as IDO1, has been one of immunology’s most tempting drug targets....
RNA Architecture Drives Coronavirus Subgenomic RNA Synthesis Across Genera
17+ hour, 5+ min ago (616+ words) Coronaviruses depend on a remarkable transcriptional strategy known as discontinuous RNA synthesis to generate the subgenomic RNAs, or sgRNAs, that allow their relatively compact genomes to express a full complement of structural and accessory proteins....